Ceftriaxone is a third generational cephalosporin that is a bactericidal antibiotic with a broad-spectrum activity against gram-positive and gram-negative bacteria. Ceftriaxone causes bacterial cell death by inhibiting cell-wall synthesis.
Ceftriaxone reaches peak plasma concentration 2-3hrs after a single intramuscular injection at approximately 30 minutes after an intravenous infusion. Elimination is via the kidney and bile, with a half-life of approximately 8hrs.
Ceftriaxone injection is usually used to treat serious infections such as septicaemia, pneumonia, and meningitis, osteomyelitis, septic arthritis, Haemophilus influenza epiglottis, surgical prophylaxis, shigellosis, invasive salmonellosis, endocarditis, gonococcal conjunctivitis, gonorrhoea, pelvic inflammatory disease, Lyme disease.
How To Reconstitute Ceftriaxone Injection
The drug molecules that are used for the reconstitution of ceftriaxone injection are of two types which are:
- Sterile Water for Injection
The drugs above are used independently when reconstituting ceftriaxone injection, that is, depending on the route of administration of ceftriaxone injection, you choose the drug to use for reconstituting the ceftriaxone injection.
If you decide to go for Intramuscular Injection (IM) you have to go lidocaine which is a local anaesthetic, it helps to lower or reduce the pain at the site of the injection, due to the fact that it inhibits transmission of pain through the nerve. So for intramuscular injection (IM) lidocaine is the best to use.
Then for Intravenous Injection (IV), sterile water for injection is used to reconstitute the ceftriaxone injection, Lidocaine can not be used due to the fact that it reduces heartbeat which will cause heart failure. It caused heart failure due to inhibiting transmission of impulse in the heart. So therefore sterile water is used is which has similar pH to that of the blood at such it’s very safe to use sterile water for injection.
Therefore next time when you choose to reconstitute your ceftriaxone depending on the route pick the best drug to reconstitute the ceftriaxone. Thank you for reading through hope it has helped a lot.